Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Results of the central data analysis.

P C Beverley¹, Y Olabiran, J A Ledermann

¹Imperial Cancer Research Fund, University College and Middlesex School of Medicine, Courtauld Institute of Biochemistry, London.

The British Journal of Cancer. Supplement

|June 1, 1991

Summary

This study characterized 87 monoclonal antibodies (mAbs) using serological and cellular analyses. The findings help compare new lung cancer mAbs and describe small cell lung cancer (SCLC) cell surface antigens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ESMO Clinical Practice Guideline Express Update on the management of epithelial ovarian cancer.

ESMO open·2026

Same author

Induction chemotherapy followed by chemoradiation in locally advanced cervical cancer: Quality of life outcomes of the GCIG INTERLACE trial.

European journal of cancer (Oxford, England : 1990)·2025

Same author

ESGO-ESMO-ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease.

Annals of oncology : official journal of the European Society for Medical Oncology·2024

Same author

Newly diagnosed and relapsed epithelial ovarian cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2023

Same author

Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline.

Annals of oncology : official journal of the European Society for Medical Oncology·2022

Same author

Efficacy of subsequent chemotherapy for patients with BRCA1/2-mutated recurrent epithelial ovarian cancer progressing on olaparib versus placebo maintenance: post-hoc analyses of the SOLO2/ENGOT Ov-21 trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2022

Area of Science:

Immunology
Oncology
Biochemistry

Background:

Monoclonal antibodies (mAbs) are crucial tools in cancer research.
Previous workshops have characterized a subset of mAbs.
Understanding the antigenic structure of small cell lung cancer (SCLC) is vital for targeted therapies.

Purpose of the Study:

To characterize a panel of 87 monoclonal antibodies (mAbs) through blind serological studies.
To compare newly developed lung cancer mAbs with existing ones.
To delineate the antigenic profile of the SCLC cell surface.

Main Methods:

Workshop participants performed immunohistochemical, immunocytological, and flow cytometric analyses.
A coded panel of 87 monoclonal antibodies was utilized.

Related Experiment Videos

Central computer analysis integrated data from multiple assays.

Main Results:

33 out of 87 mAbs were assigned to seven distinct clusters.
Two novel antigens identified by mAbs have been cloned.
Two additional antigens were defined as carbohydrate epitopes.
The study facilitated comparison of new lung cancer mAbs with established ones.

Conclusions:

The workshop successfully clustered a significant number of monoclonal antibodies.
The identified antigens and epitopes provide insights into SCLC cell surface composition.
These findings contribute to a better understanding of lung cancer immunology and potential therapeutic targets.