Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elementary neuronal dysfunctions in schizophrenia.

R Freedman1, M Waldo, P Bickford-Wimer

  • 1Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262.

Schizophrenia Research
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Species-specific thermal classification schemes can improve climate related marine resource decisions.

PloS one·2021
Same author

The relationship between the glenoid track and the range of shoulder motion: A cadaver study.

Orthopaedics & traumatology, surgery & research : OTSR·2018
Same author

Publishing what's important.

Acta psychiatrica Scandinavica·2015
Same author

Outcome of Bankart repair in contact versus non-contact athletes.

Orthopaedics & traumatology, surgery & research : OTSR·2015
Same author

A compact high-performance low-field NMR apparatus for measurements on fluids at very high pressures and temperatures.

The Review of scientific instruments·2014
Same author

Long-term beneficial effects of adrenal medullary autografts supported by nerve growth factor in Parkinson's disease.

European journal of neurology·2013

People with schizophrenia have a sensory gating deficit, impairing their ability to filter sensory information. This fundamental issue may explain hypervigilance and attention difficulties in schizophrenia patients.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Sensory gating, measured by the P50 auditory-evoked potential, is a mechanism for regulating attention.
  • Normal individuals show a diminished response to a second paired sound, indicating effective sensory gating.
  • Schizophrenia is often characterized by deficits in sensory processing and attention.

Purpose of the Study:

  • To investigate the elementary sensory processing deficit in schizophrenia.
  • To explore the role of sensory gating in the pathophysiology of schizophrenia.

Main Methods:

  • Auditory-evoked potentials, specifically the P50 wave, were used to measure sensory gating.
  • Paired sound stimuli were presented to individuals with schizophrenia and control subjects.

Related Experiment Videos

Main Results:

  • Schizophrenia patients exhibit a deficient sensory gating mechanism, with a significantly reduced P50 wave response to the second sound.
  • This deficit suggests impaired regulation of sensory input and a potential link to hypervigilance.
  • The deficiency appears to have a genetic basis and involves brainstem pathways influencing the hippocampus.

Conclusions:

  • An elementary sensory gating deficit is a core feature of schizophrenia.
  • This deficit may underlie complex psychotic symptoms like hallucinations and delusions.
  • Understanding the neurobiology of sensory gating deficits is crucial for schizophrenia research.