Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CCL5 modulates pneumococcal immunity and carriage.

Ravichandran Palaniappan1, Shailesh Singh, Udai P Singh

  • 1Mercer University, Atlanta, GA 30341, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|February 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections.

Science translational medicine·2026
Same author

Neuregulin-1 Mitigates Kidney Injury in Humanized Sickle Cell Mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Integrated systems biology reveals an 8-gene signature predicting early-stage lung adenocarcinoma progression and patient survival.

Scientific reports·2025
Same author

Investigating SMR Peptide Interactions with Breast Cancer-Associated Proteins.

International journal of molecular sciences·2025
Same author

Stratifying ALS Patients by Mode of Inheritance Reveals Transcriptomic Signatures Specific to sALS and fALS.

International journal of molecular sciences·2025
Same author

Revolutionizing Oncology Through AI: Addressing Cancer Disparities by Improving Screening, Treatment, and Survival Outcomes via Integration of Social Determinants of Health.

Cancers·2025

Chemokine CCL5 is crucial for protective immunity against pneumococcal infections. Blocking CCL5 impairs T cell responses and antibody production, increasing susceptibility to pneumonia.

Area of Science:

  • Immunology
  • Microbiology
  • Infectious Diseases

Background:

  • Pneumococcal carriage and pneumonia pose significant public health challenges.
  • Genetic factors influencing chemokine expression, like CCL5, can impact infectious disease susceptibility.
  • CCL5 (C-C motif chemokine ligand 5) plays a role in immune responses.

Purpose of the Study:

  • To investigate the role of CCL5 in adaptive immunity against Streptococcus pneumoniae.
  • To determine if CCL5 is essential for developing protective immunity to pneumococcal carriage and pneumonia.

Main Methods:

  • Mice were treated with anti-CCL5 antibodies or controls during Streptococcus pneumoniae challenge.
  • Immune cell populations (CD4+, CD8+, CD11b+) in lymphoid tissues and lungs were analyzed.

Related Experiment Videos

  • Humoral (antibody) and cellular (T cell cytokine) immune responses were measured.

    • Main Results:

    • CCL5 blockade reduced T cells and CD11b+ cells in lymphoid tissues and lungs.
    • CCL5 inhibition decreased antigen-specific IgG and IgA antibody levels.
    • Blocking CCL5 altered T cell cytokine profiles, favoring IL-10 and reducing IL-4/IFN-gamma, correlating with increased pneumonia severity.

    Conclusions:

    • CCL5 is essential for inducing and maintaining protective immunity against pneumococcal infections.
    • CCL5 blockade disrupts key components of the adaptive immune response, leading to increased susceptibility to pneumococcal pneumonia.