Related Experiment Videos
Dibutyryl-cAMP induces SNAP-25 translocation into the neurites in PC12
P P Sanna1, F E Bloom, M C Wilson
1Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Brain Research. Developmental Brain Research
|March 18, 1991
Abstract:
SNAP-25 immunoreactivity was translocated into the endings of the processes induced in PC12 cells by dibutyryl-cAMP-treatment. Conversely, the protein was not present in the endings of the processes seen after NGF-treatment unless dibutyryl-cAMP was used simultaneously. This redistribution of SNAP-25 immunoreactivity appeared to be dependent upon new protein synthesis. Finally, dibutyryl-cAMP was capable of inducing SNAP-25 expression.