Related Experiment Video
Updated: Aug 11, 2026
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Malignant meningioma as a second malignancy after therapy for acute lymphatic leukemia without cranial radiation
J P Regel1, B Schoch, I E Sandalcioglu
1Department of Neurosurgery, University Medical School Essen, Hufelandstrasse 55, 45122, Essen, Germany. jens.regel@uni-essen.de
Rationale:
Meningiomas in the pediatric age group are very rare tumors, comprising about 1-4.2% of all primary pediatric intracranial tumors.
Case Report:
We present a 17-year-old patient who suffered from an intraventricular malignant meningioma. At the age of 2 years, acute lymphatic leukemia (common ALL [cALL]) was diagnosed and successfully treated with chemotherapy. There was no cranial radiation therapy. In December 2001, 13 years after diagnosis of cALL, he complained of headache, vomiting, and walking difficulties. Magnetic resonance imaging showed an enhancing mass with cystic components in the trigone of the right lateral ventricle. The tumor was removed completely. Histological diagnosis revealed a malignant papillary meningioma. After removal of a recurrent meningioma 16 months later, he received local radiotherapy.
Conclusion:
Pathogenetic mechanisms, treatment options, and prognosis of meningiomas and secondary malignancies of this age group are discussed.
Insights
Pediatric meningiomas are rare. This case highlights a rare intraventricular malignant meningioma in a 17-year-old with a history of acute lymphatic leukemia, emphasizing the need for careful monitoring and treatment strategies.
Area of Science:
- Neuro-oncology
- Pediatric oncology
Background:
- Meningiomas are rare in children, accounting for 1-4.2% of pediatric intracranial tumors.
- Secondary malignancies can arise after cancer treatment.
Observation:
- A 17-year-old male presented with symptoms of increased intracranial pressure.
- He had a history of acute lymphatic leukemia (cALL) treated with chemotherapy but no cranial radiation.
- MRI revealed an intraventricular mass in the right lateral ventricle trigone.
Findings:
- Complete tumor resection was performed.
- Histological examination confirmed a malignant papillary meningioma.
- A recurrence 16 months later required further surgery and radiotherapy.
Implications:
- This case underscores the importance of considering secondary meningiomas in pediatric cancer survivors.
- Discusses pathogenetic mechanisms, treatment strategies, and prognosis for pediatric meningiomas.
- Highlights the rarity of intraventricular malignant meningiomas in this age group.
