[HLA-DRB1 polymorphism in the Ewenki Ethnic of Inner Mongolian]
Rong Hai1, Li-fu Bi, Xiu-lan Su
1Clinical Medical Research Center, Inner Mongolian Medical College, Huhehhte, Inner Mongolian 010050, P.R. China.
Objective:
To study the HLA-DRB1 genetic polymorphism in the Ewenki of Inner mongolia.
Methods:
HLA-DRB1 allele polymorphisms in 84 normal Ewenki were determined by PCR with sequencing based typing (SBT).
Results:
Twenty-five HLA-DRB1 alleles were observed. The allele frequency of HLA-DRB1*03011(14.88%) is the highest; the allele frequencies of HLA -DRB1*09012 (13.69%), DRB1*07011(8.92%), DRB1*04011(9.52%) and DRB1*12011(8.33%) are lower.
Conclusion:
The distribution of HLA-DRB1 alleles frequencies in normal Ewenki from Inner Mongolia exhibits a unique profile, which is of important reference value for studies on anthropology and related illnesses in Ewenki population.
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