Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Langerhans cells].

Jenny Valladeau1

  • 1Université Lyon I, EA 3732, Hôpital Edouard-Herriot, Pavillon R, 69437 Lyon Cedex 03, France. valladeau@lyon.inserm.fr

Medecine Sciences : M/S
|February 7, 2006
PubMed
Summary

Epidermal Langerhans cells are key skin immune cells with diverse functions beyond the skin. This review details their characteristics and life-cycle stages within the skin.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Poly(I:C)-Treated human langerhans cells promote the differentiation of CD4+ T cells producing IFN-gamma and IL-10.

The Journal of investigative dermatology·2009
Same author

Structural studies of langerin and Birbeck granule: a macromolecular organization model.

Biochemistry·2009
Same author

Early events in HIV transmission through a human reconstructed vaginal mucosa.

AIDS (London, England)·2008
Same author

Human Langerhans cells express a specific TLR profile and differentially respond to viruses and Gram-positive bacteria.

Journal of immunology (Baltimore, Md. : 1950)·2006
Same author

Mixed Langerhans cell and interstitial/dermal dendritic cell subsets emanating from monocytes in Th2-mediated inflammatory conditions respond differently to proinflammatory stimuli.

Journal of leukocyte biology·2006
Same author

The HIV-1 clade C promoter is particularly well adapted to replication in the gut in primary infection.

AIDS (London, England)·2006

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Langerhans cells (LC) are crucial components of the skin's immune system.
  • These cells possess diverse functions impacting various physiological and pathological processes.
  • Their role extends beyond the skin, influencing systemic immunity.

Purpose of the Study:

  • To review the fundamental characteristics of epidermal Langerhans cells.
  • To emphasize the features of Langerhans cells throughout their life-cycle stages within the skin.

Main Methods:

  • Literature review of existing research on Langerhans cells.
  • Analysis of cellular functions, including internalization and migration.
  • Focus on in-skin life-cycle stages.

Main Results:

  • Langerhans cells internalize particulate agents and macromolecules.
  • They exhibit migratory properties, traveling from skin to lymph nodes.
  • LC interact with T lymphocytes in lymph nodes.

Conclusions:

  • Epidermal Langerhans cells play a pivotal role in skin immunity.
  • Their functions are critical in infectious diseases, allergies, inflammation, and transplantation.
  • Understanding their in-skin life-cycle is essential for comprehending their broader immunological impact.

Related Experiment Videos