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Updated: Aug 11, 2026
10:05
Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
Published on: January 25, 2017
Geriatric neutrophils: implications for older adults
Margaret H Crighton1, Alicia A Puppione
1University of Pittsburgh School of Nursing, Pittsburgh, PA, USA. crighton@pitt.edu
Seminars in Oncology Nursing
|February 7, 2006
Summary
Older adults with cancer face increased infection risk due to immunosenescence (age-related immune decline), especially with neutropenia. More research is needed on immunosenescence and neutropenia in this population.
Area of Science:
- Gerontology
- Immunology
- Oncology
Background:
- Immunosenescence, characterized by age-related immune system alterations, increases susceptibility to infections.
- Cancer and its treatments exacerbate this vulnerability, particularly in older adults.
- Supportive care for neutropenic older adults with cancer often overlooks immunosenescence.
Observation:
- The innate immune system is significantly impacted by immunosenescence.
- Neutropenia, a common side effect of cancer treatment, further compromises immune defenses.
- Older adults with cancer experience a magnified risk of infection due to combined immunosenescence and neutropenia.
Findings:
- Age-related immune decline (immunosenescence) enhances vulnerability to infections in older adults.
- Cancer and its therapies intensify the risks associated with neutropenia and immunosenescence.
- Current supportive care strategies inadequately address the interplay of immunosenescence and neutropenia in elderly cancer patients.
Implications:
- Further research is essential to understand the specific impact of immunosenescence on neutropenia and patient outcomes.
- Clinical practice requires updated guidelines that integrate immunosenescence considerations for neutropenic older adults with cancer.
- Developing targeted interventions for this demographic is crucial for improving infection prevention and supportive care.
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