Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Control by cholinergic mechanisms.

Kurt Racké1, Uwe R Juergens, Sonja Matthiesen

  • 1Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, D-53113 Bonn, Germany. racke.kurt@uni-bonn.de

European Journal of Pharmacology
|February 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy.

The European respiratory journal·2021
Same author

New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach.

Advances in therapy·2020
Same author

Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor.

The Journal of pharmacology and experimental therapeutics·2017
Same author

Metabolic role of dipeptidyl peptidase 4 (DPP4) in primary human (pre)adipocytes.

Scientific reports·2016
Same author

Non-small cell lung cancer cell survival crucially depends on functional insulin receptors.

Endocrine-related cancer·2015
Same author

Dual regulation of β2-adrenoceptor messenger RNA expression in human lung fibroblasts by β2-cAMP signaling; delayed upregulated inhibitors oppose a rapid in onset, direct stimulation of gene expression.

Naunyn-Schmiedeberg's archives of pharmacology·2014

Acetylcholine, a neurotransmitter and paracrine mediator in the respiratory tract, acts on numerous cell types via nicotinic and muscarinic receptors. This review details its synthesis, release, and diverse functions in respiratory system regulation.

Area of Science:

  • Respiratory system physiology
  • Neuropharmacology
  • Cell signaling

Background:

  • Acetylcholine functions as both a neurotransmitter and paracrine mediator in the respiratory tract.
  • Non-neuronal cells contribute to acetylcholine synthesis and release.
  • Respiratory tract cells express diverse acetylcholine receptors.

Purpose of the Study:

  • To review the mechanisms of acetylcholine synthesis and release from neuronal and non-neuronal cells.
  • To outline the different types of cholinoceptors and their signaling pathways.
  • To discuss the role of acetylcholine in modulating respiratory tract cell functions.

Main Methods:

  • Literature review of studies on acetylcholine in the respiratory tract.
  • Analysis of mechanisms for acetylcholine synthesis and release.

Related Experiment Videos

  • Examination of nicotinic and muscarinic receptor subtypes and signaling.
  • Discussion of acetylcholine's impact on various target cells.

    • Main Results:

    • Acetylcholine is synthesized and released by both neuronal and non-neuronal cells in the respiratory tract.
    • Multiple subtypes of nicotinic and muscarinic receptors are present on respiratory cells.
    • Acetylcholine modulates the function of smooth muscles, nerves, epithelial cells, secretory cells, fibroblasts, and inflammatory cells.

    Conclusions:

    • Acetylcholine plays a multifaceted role in the respiratory system, extending beyond neurotransmission.
    • Understanding acetylcholine's non-neuronal functions and receptor signaling is crucial for respiratory health.
    • Further research into acetylcholine's precise roles can inform therapeutic strategies for respiratory diseases.