Related Experiment Video
Updated: Aug 11, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Antifungal properties of new series of quinoline derivatives
Robert Musiol1, Josef Jampilek, Vladimir Buchta
1Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland.
Abstract:
The series of quinoline derivatives were prepared. The synthetic approach, analytical, and spectroscopic data of all synthesized compounds are presented. All the prepared derivatives were analyzed using the reversed-phase high performance liquid chromatography (RP-HPLC) method for the lipophilicity measurement. In the present study, the correlation between RP-HPLC retention parameter log K (the logarithm of capacity factor K) and various calculated log P data is shown. The relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well. The prepared compounds were tested for their in vitro antifungal activity. 2-[(3-Hydroxyphenylimino)methyl]quinolin-8-ol (8), 2-[(4-hydroxyphenylimino)methyl]quinolin-8-ol (9) and 2-[(2,5-dichloro-4-nitrophenylamino)methoxymethyl]quinolin-8-ol (10) showed in vitro antifungal activity comparable to or higher than that of the standard fluconazole. Structure-activity relationships among the chemical structure, the physical properties, and the biological activities of the evaluated compounds are discussed in the article.
Related Concept Videos
Antifungal Agents
Anthelminthic Agents
Antiviral Nucleoside Inhibitors
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Antiprotozoal Agents
Inhibitors of Bacterial DNA Synthesis

