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CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation

Olivier Joffre1, Joost P M van Meerwijk

  • 1Tolerance and Autoimmunity Section, INSERM U563, Université Paul Sabatier, IFR 30, Purpan Hospital, BP 3028, 31024 Toulouse Cedex 3, France.

Seminars in Immunology
|February 7, 2006
PubMed

Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens. The most potent self-tolerance mechanism is probably dominant tolerance assured by regulatory and suppressor T lymphocytes. It appears therefore attractive to use the same mechanism to induce transplantation-tolerance. We here review and discuss recent advances in the use of one of the best-characterized regulatory T lymphocyte populations, CD4(+)CD25(+) T cells, to prevent graft-versus-host disease and bone marrow allograft rejection.

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