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Adaptive radiotherapy for invasive bladder cancer: a feasibility study.
Floris J Pos1, Maarten Hulshof, Joos Lebesque
1Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. f.pos@nki.nl
International Journal of Radiation Oncology, Biology, Physics
|February 7, 2006
Summary
Adaptive radiotherapy (ART) for bladder cancer is feasible and effective. This approach accurately targets tumors, reduces treatment volumes by 40%, and minimizes errors from bladder tumor movement.
Area of Science:
- Radiation Oncology
- Urologic Oncology
- Medical Physics
Background:
- Bladder cancer treatment requires precise radiation delivery.
- Tumor and organ motion can lead to treatment inaccuracies.
Purpose of the Study:
- To assess the feasibility of adaptive radiotherapy (ART) for bladder cancer.
- To evaluate ART combined with partial bladder irradiation.
Main Methods:
- Twenty-one patients with T1-T4 N0M0 bladder cancer were included.
- Daily CT scans were used to create an adaptive planning target volume (PTV(ART)).
- Treatment accuracy was evaluated using repeat CT scans.
Main Results:
- Adaptive radiotherapy (ART) reduced treatment volumes by an average of 40% compared to conventional planning (PTV(CONV)).
- The gross tumor volume (GTV) was adequately covered by PTV(ART) in 95% of repeat scans.
- Only one scan showed inadequate GTV coverage by the 95% isodose on treatment planning.
Conclusions:
- Adaptive radiotherapy is an effective strategy for bladder cancer.
- ART addresses treatment errors due to bladder tumor positional variations.
- This method significantly reduces radiation treatment volumes.