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Updated: Aug 11, 2026

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Misleading effects of clonazepam in symptomatic electrical status epilepticus during sleep syndrome
Nadia Bahi-Buisson1, Rosanna Savini, Monica Eisermann
1Département de Pédiatrie, Service de Neuropédiatrie et Maladies Métaboliques, Hôpital Necker, Paris, France. nadia.bahi-buisson@nck.ap-hop-paris.fr
Abstract:
Electrical status epilepticus during sleep syndrome and its variants are age-dependent epileptic encephalopathies associated with a sleep-related electroencephalographic pattern of continuous spike-waves, combined with motor or cognitive impairment. These epileptic encephalopathies are usually not responsive to conventional antiepileptic drugs. This report describes two children in whom clonazepam had no effect on cognitive and motor disorders but controlled spike activity, preventing a proper diagnosis. Withdrawal of clonazepam was accompanied by the recurrence of continuous spike-waves in slow sleep, permitting the diagnosis of electrical status epilepticus during sleep syndrome and appropriate therapeutic decisions. These two cases of the misleading effect of clonazepam in electrical status epilepticus during sleep syndrome illustrate the puzzling situation that can occur when therapeutic options only consider the electroencephalographic features without prior syndromic diagnosis.
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