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Related Experiment Videos

Receptors regulating acid secretion.

M J Lewin1, A Bado

  • 1Gastroenterologic Research Unit, INSERM U.10. Hôpital Bichat, Paris, France.

Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1991
PubMed
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Histamine H2 receptors on parietal cells are 70-kDa glycoproteins activating adenylate cyclase via Gs protein. This increases cAMP, crucial for gastric acid secretion.

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Cellular Physiology

Background:

  • Histamine H2 receptors mediate gastric acid secretion via parietal cells.
  • The biochemical nature of the H2 receptor was recently elucidated.
  • H2 receptors share structural similarities with beta 2-adrenergic receptors and G protein-coupled receptors.

Purpose of the Study:

  • To detail the biochemical nature and signaling pathway of the histamine H2 receptor.
  • To explore histamine's role in intracellular calcium regulation.
  • To investigate the involvement of the H3 histamine receptor in gastric acid secretion.

Main Methods:

  • Biochemical characterization of the H2 receptor.
  • Analysis of G protein involvement (Gs, cholera toxin, pertussis toxin).

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  • Measurement of cyclic AMP (cAMP) levels and intracellular calcium concentrations.

    • Main Results:

    • The H2 receptor is a 70-kDa glycoprotein linked to adenylate cyclase via a Gs protein.
    • Histamine stimulation increases cAMP production, activating a Cl- channel linked to the (H+,K+)-ATPase.
    • Histamine also causes a transient increase in intracellular Ca2+ concentration.
    • Evidence suggests an H3 receptor also regulates gastric acid secretion.

    Conclusions:

    • The elucidated H2 receptor structure and signaling pathway provide insight into gastric acid secretion regulation.
    • Further research is needed to explain histamine's effect on intracellular calcium and the H3 receptor's role.