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Updated: Aug 11, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
Published on: June 13, 2025
Linking molecular motors to Alzheimer's disease
Gorazd B Stokin1, Lawrence S B Goldstein
1Institute of Clinical Neurophysiology, Division of Neurology, University Medical Center, Zaloska Cesta 7, SI-1525 Ljubljana, Slovenia.
Abstract:
It is currently thought that Alzheimer's disease develops due to aberrant generation of amyloid-beta peptides. However, the mechanisms underlying the aberrant generation of amyloid-beta peptides remain unknown. An emerging concept suggests that impaired axonal transport may play a pivotal role in the aberrant generation of amyloid-beta peptides. Here we review and discuss advances in understanding AD with the primary focus on the possible role of molecular motors and axonal transport in its pathogenesis.
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