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Updated: Dec 8, 2025

Isolation and Ex Vivo Culture of Vδ1+CD4+γδ T Cells, an Extrathymic αβT-cell Progenitor
Published on: December 7, 2015
T lineage progenitors: the earliest steps en route to T lymphocytes
1The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria, 3050, Australia. wu@wehi.edu.au
Abstract:
T lymphocyte development in the thymus is a tightly regulated stepwise process. The identification and characterization of the earliest T lineage progenitors and their downstream progeny now enables the study of important cellular and molecular mechanisms that control and regulate T lineage commitment and differentiation. Significant progress has been made recently on the developmental relationships of the various cells with T cell progenitor activity identified in mouse bone marrow, blood and thymus, and on the molecular regulation of progenitor homing to the thymus. The essential role of Notch-1 signalling in intrathymic T lineage commitment and subsequent T cell development has been clearly documented.
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