Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differential gene expression in the developing mouse ureter.

Eleanor K L Mitchell1, Darrin F Taylor, Kyra Woods

  • 1Department of Anatomy and Cell Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.

Gene Expression Patterns : GEP
|February 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Birth Weight Measurement Gaps and Global Kidney Health.

Kidney360·2026
Same author

Classification of indeterminate and off-target cell types within human kidney organoid differentiation.

iScience·2026
Same author

Application of spatial transcriptomics across organoids for a high-resolution, spatial whole-transcriptome benchmarking dataset.

iScience·2026
Same author

Integrating nephron number into risk stratification for IgA nephropathy.

Clinical and experimental nephrology·2026
Same author

The Impact of Low-Protein Diet on the Molecular and Cellular Development of the Fetal Kidney.

Journal of the American Society of Nephrology : JASN·2026
Same author

The emergence of multiple testicular cell lineages in human stem cell-derived testis-like organoids.

Development (Cambridge, England)·2026

Researchers identified novel genes crucial for ureter development by comparing gene expression in mouse ureters at different developmental stages. This study provides insights into the molecular basis of kidney and urinary tract malformations.

Area of Science:

  • Developmental Biology
  • Genomics
  • Urology

Background:

  • Kidney dysgenesis often stems from ureter development defects.
  • While some genes are known, many causes of ureter abnormalities remain unclear.

Purpose of the Study:

  • To identify novel genes involved in mouse ureter development.
  • To understand the molecular mechanisms underlying kidney and lower urinary tract malformations.

Main Methods:

  • Comparative gene expression analysis using mouse long oligo microarrays at embryonic day (E) 12.5, E15.5, and postnatal day (P) 75.
  • In situ hybridization to determine spatial gene expression patterns.

Main Results:

  • Identified 248 upregulated and 208 downregulated genes between E12.5 and P75.

Related Experiment Videos

  • Observed upregulation of known ureteric mesenchyme (foxC1, foxC2), urothelium (UPIIIa, RAB27b, PPARgamma), and smooth muscle genes (Acta1, Tnnt2, Myocd, Tpm2) corresponding to developmental stages.
  • Discovered novel genes (Acta1, Thbs2, Col5a2, Kcnj8, Adh1) with specific spatial expression in ureter tissues.

    • Conclusions:

    • This study presents the first global gene expression profile of the developing mouse ureter.
    • The identified genes offer new insights into the molecular pathways regulating ureter formation and associated congenital anomalies.