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Identification of human papillomavirus antigen in a bladder tumor
F Roussel1, J M Picquenot, O Rousseau
1Department of Histology and Embryology, Charles Nicolle Hospital, University and Regional Medical Center, Rouen, France.
Acta Cytologica
|May 1, 1991
Abstract:
Human papillomavirus (HPV) antigen was found in one of six noninfiltrating (grade II) carcinomas of the bladder. The antigen was located in the nuclei of the superficial cells. This virus-bearing tumor occurred in a patient with no known risk factors. The presence of HPV in low-grade urinary lesions seems to be frequent and may reflect the early stages of carcinogenesis; in fact, HPV infections may cause papillomas and carcinomas of the urothelial mucosae as well as the genital mucosae.