Related Experiment Video
Updated: Aug 11, 2026
Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Effects of probiotics on radiation-induced intestinal injury in rats
Seher Demirer1, Semih Aydintug, Belma Aslim
1Ankara University School of Medicine, Ankara, Turkey. demirers02@yahoo.com
Objective:
Radiotherapy is an important aspect of multimodal cancer therapy, but radiation-induced acute intestinal injury is a common and serious problem. Disruption of morphologic mucosal integrity and normal bacterial microflora after abdominal radiation leads to malabsorption and bacterial translocation.
Methods:
Lactobacillus bulgaricus strain isolated from yogurt was given as a probiotic to rats subjected to radiotherapy. On postradiation day 8 rats were killed. Mesenteric lymph nodes, liver, and spleen were excised for microbiologic examinations. Segments of jejunum, ileum, and colon were evaluated for the presence of inflammation, vascularity, and mucus cells.
Results:
The results of this study suggest that probiotics may have a protective effect on intestinal mucosa.
Conclusion:
Probiotics added as substrates can be given by an oral or enteral route to patients who undergo radiotherapy to prevent radiation-induced enteritis and related malnutrition.
