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Published on: June 15, 2011
Schizophrenia, antipsychotics and diabetes: Genetic aspects
1Department of Psychiatry, CHU Henri-Mondor, 94010 Créteil cedex, France. bellivier@im3.inserm.fr
Summary
Shared genetic factors may link type 2 diabetes and schizophrenia, indicated by family studies and overlapping genetic loci. Further research is needed to confirm the genetic basis for this comorbidity.
Area of Science:
- Genetics
- Psychiatry
- Endocrinology
Background:
- Type 2 diabetes and schizophrenia exhibit high comorbidity, suggesting shared biological underpinnings.
- Family studies show increased diabetes risk in schizophrenia patients' relatives, pointing to heritable susceptibility.
- Genetic linkage analyses reveal overlapping loci associated with both schizophrenia and type 2 diabetes.
Purpose of the Study:
- To explore the potential shared genetic basis for the comorbidity of type 2 diabetes and schizophrenia.
- To review evidence from family, linkage, and candidate gene studies.
- To identify potential neurochemical pathways involved in antipsychotic-induced diabetes.
Main Methods:
- Review of family studies demonstrating heritable susceptibility.
- Analysis of linkage studies identifying shared chromosomal loci (e.g., 2p22.1-p13.2, 6g21-824.1).
- Examination of candidate genes (e.g., dopamine D5 receptor, tyrosine hydroxylase) and neurochemical substrates (e.g., histamine H1, 5-HT2C, beta3 adrenoreceptor).
Main Results:
- Several genetic loci are associated with both conditions.
- Specific genes and receptors are implicated as potential candidates.
- Antipsychotic treatment is linked to increased type 2 diabetes rates, possibly via neurochemical pathways.
Conclusions:
- A shared genetic susceptibility between type 2 diabetes and schizophrenia is plausible.
- The genetic basis for this association requires extensive further investigation.
- Systematic screening of susceptibility loci and quantitative trait locus mapping are recommended.
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