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Computed tomographic characterization of malignant peritoneal mesothelioma
Tristan Dongbo Yan1, Namik Haveric, Carlos Pablo Carmignani
1Program in Peritoneal Surface Malignancy, Washington Cancer Institute, Washington Hospital Center, DC 20010, USA.
Tumori
|February 8, 2006
Summary
Malignant peritoneal mesothelioma predominantly affects central and pelvic abdomen. CT scans with Z-scores can aid in its radiologic diagnosis and characterization.
Area of Science:
- Oncology
- Radiology
- Abdominal Imaging
Background:
- Peritoneal mesothelioma is a rare, typically fatal cancer.
- Cytoreductive surgery and intraperitoneal chemotherapy offer potential for long-term survival in select patients.
- Early recognition and surgical planning are crucial for optimizing treatment outcomes.
Purpose of the Study:
- To evaluate the utility of computed tomography (CT) in characterizing malignant peritoneal mesothelioma.
- To identify common sites of tumor involvement and assess disease distribution using Z-scores.
- To explore the potential of CT findings for primary radiologic diagnosis.
Main Methods:
- Retrospective review of CT scans from 33 patients with malignant peritoneal mesothelioma.
- Analysis of CT findings by abdominopelvic anatomic sites (16) and regions (9).
- Application of Z-scores to assess tumor incidence at specific sites and presence of ascites.
Main Results:
- The vesical/rectal uterine pouch (97%) and greater omentum (91%) showed highest involvement.
- Central and pelvic abdominopelvic regions exhibited Z-scores >2 for large volume disease.
- Ascites was present in 66% of patients; small bowel enlargement occurred in approximately one-third.
Conclusions:
- CT evaluation reveals predominant tumor mass in the central and pelvic abdomen for malignant peritoneal mesothelioma.
- Z-scores and CT findings, including small bowel changes, can facilitate radiologic characterization.
- This approach may enable primary radiologic diagnosis of malignant peritoneal mesothelioma.
