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Overexpression of human TRK proto-oncogene into mouse cells using an inducible vector system
1Developmental Oncology Section, National Cancer Institute-Frederick Cancer Research Facility, Maryland 21701.
Biochemical and Biophysical Research Communications
|May 31, 1991
Abstract:
The TRK proto-oncogene encodes a tyrosine kinase receptor for an, as yet, unidentified ligand. In order to help the identification of this ligand, we have constructed an expression vector capable of overexpressing the TRK protein in an inducible fashion. We report here the characterization of the TRK proto-oncogene products obtained from this expression vector.