Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis.

U Nocentini1, P Pasqualetti, S Bonavita

  • 1Department of Neurology, University of Rome 'Tor Vergata' and IRCCS 'S. Lucia' Foundation, Rome, 00179 Italy. u.nocentini@hsantalucia.it

Multiple Sclerosis (Houndmills, Basingstoke, England)
|February 8, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of maternal feed restriction on placental lactogen and its correlation with pregnancy-associated glycoproteins in pregnant ewes.

Theriogenology·2026
Same author

Women and multiple sclerosis: From gender medicine to precision medicine.

Multiple sclerosis and related disorders·2025
Same author

Hereditary Spastic Paraplegia Associated with Ultra-Rare Variant Enrichment Encompassing the SYNE1, CAPN1 and PGAP1 Genes.

Cerebellum (London, England)·2024
Same author

Hypogammaglobulinemia and severe infections in Multiple Sclerosis patients on anti-CD20 agents: A multicentre study.

Multiple sclerosis and related disorders·2024
Same author

Comparative effectiveness and cost-effectiveness of natalizumab and fingolimod in rapidly evolving severe relapsing-remitting multiple sclerosis in the United Kingdom.

Journal of medical economics·2023
Same author

Reduced left ventricular function and sustained hypertension in women seven years after severe preeclampsia.

Scandinavian cardiovascular journal : SCJ·2022
Same journal

Impact of multiple sclerosis disease-modifying therapies on chronic lesion tissue expansion.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Tobacco smoking disrupts bile acid and tryptophan metabolism in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Missed radiologic disease activity by conventional side-by-side MRI comparison is associated with future disease activity in multiple sclerosis: Adopting semiautomated coregistration-fusion into clinical practice.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Longitudinal magnetic resonance spectroscopy study of metabolite changes over 2 years in relapsing and primary progressive multiple sclerosis treated with ocrelizumab.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Racial identity, marginalization, and depression in pediatric-onset multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Disability and race in MS: Does socioeconomic disadvantage play a role?

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
See all related articles
This summary is machine-generated.

Cognitive dysfunction affects 31% of relapsing-remitting multiple sclerosis (RRMS) patients, with information processing speed and memory most commonly impaired. These deficits may serve as early markers for cognitive impairment in MS.

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Psychology

Background:

  • Cognitive dysfunction is a key clinical feature of multiple sclerosis (MS).
  • Prevalence data for cognitive dysfunction in MS, particularly in the relapsing-remitting form (RRMS), are inconsistent in existing literature.
  • Specific data on cognitive domain impairment in RRMS patients are often not separately presented.

Purpose of the Study:

  • To investigate cognitive impairment across various domains in a cohort of 461 relapsing-remitting multiple sclerosis patients.
  • To determine the prevalence and severity of cognitive deficits in this RRMS sample.
  • To identify specific cognitive domains most affected and potential early markers of impairment.

Main Methods:

  • A battery of neuropsychological tests, including the Mental Deterioration Battery, SDMT, and MCST, was administered to 461 RRMS patients.

Related Experiment Videos

  • Patients were assessed for cognitive deficits across multiple domains.
  • Cluster analysis was used to subgroup patients based on cognitive performance.

    • Main Results:

    • Using the Mental Deterioration Battery, 31% of the selected RRMS sample exhibited cognitive deficits (15% mild, 11.2% moderate, 4.8% severe).
    • Information processing speed was the most frequently impaired domain, followed by memory.
    • When additional tests were included, 39.3% of patients showed impairment in two or more cognitive domains. Deficits in processing speed and memory distinguished unimpaired from mildly impaired patients.

    Conclusions:

    • Information processing speed deficits appear to be an early and significant indicator of cognitive impairment in multiple sclerosis patients.
    • Despite sample limitations, the study highlights the substantial prevalence of cognitive dysfunction in RRMS.
    • Cognitive and clinical characteristics showed significant associations, though further research is needed to clarify their clinical relevance.