Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recoding in bacteriophages and bacterial IS elements.

Pavel V Baranov1, Olivier Fayet, Roger W Hendrix

  • 1Bioscience Institute, University College Cork, Cork, Ireland.

Trends in Genetics : TIG
|February 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.

Nature communications·2026
Same author

Human SRD5A1 as a case of gene expression indel-resistance in triple-coding region.

Genome biology·2026
Same author

Expanding the human proteome with microproteins and peptideins.

Nature·2026
Same author

Mechanism of ribosome stalling by the AMD1 C-terminal tail arrest peptide.

Science advances·2026
Same author

An expanded reference catalog of translated open reading frames for biomedical research.

Nucleic acids research·2026
Same author

Molecular architecture and diversity of StopGo/2A translational recoding.

Proceedings of the National Academy of Sciences of the United States of America·2026

Programmed ribosomal frameshifting and stop codon read-through allow gene expression versatility in phages and bacteria. These nonstandard decoding mechanisms are crucial for mobile genetic elements and offer insights into gene regulation.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Gene expression relies on precise decoding of mRNA sequences.
  • Variations in decoding, such as frameshifting and read-through, are observed across life.
  • These nonstandard decoding events are particularly prevalent in viral and bacterial mobile genetic elements.

Purpose of the Study:

  • To investigate programmed ribosomal frameshifting, stop codon read-through, and transcriptional slippage.
  • To explore the role of these mechanisms in the decoding of phage and bacterial mobile element genes.
  • To highlight the significance of nonstandard decoding in diverse organisms.

Main Methods:

  • Analysis of mRNA sequences and genetic elements.
  • Bioinformatic identification of novel sequences associated with programmed decoding alterations.

Related Experiment Videos

  • Review of existing literature on nonstandard gene decoding.

    • Main Results:

    • Programmed ribosomal frameshifting and stop codon read-through are key mechanisms for versatile gene expression.
    • Phage genes and bacterial mobile elements are rich sources of nonstandard decoding events.
    • Novel sequences enabling programmed gene decoding alterations have been identified.

    Conclusions:

    • Nonstandard decoding mechanisms contribute significantly to the functional repertoire of genes.
    • Understanding these alterations provides insights into gene regulation and evolution.
    • Further research into these sequences will illuminate the broader landscape of gene decoding.