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Related Experiment Videos

Tissue-specific expression of Clec2g in mice.

Yoshinao Katsu1, Taisen Iguchi

  • 1Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan.

European Journal of Cell Biology
|February 8, 2006
PubMed
Summary

This study identifies DDV10, a novel C-type lectin, as a key regulator in mouse vaginal epithelial cell differentiation. DDV10 expression is linked to stratification and cornification, suggesting its role in epithelial tissue development.

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Area of Science:

  • Reproductive Biology
  • Molecular Endocrinology
  • Epithelial Cell Biology

Background:

  • Estrogens are critical for regulating vaginal epithelial cell proliferation and differentiation.
  • The specific molecular mechanisms underlying epithelial stratification and cornification are not fully elucidated.

Purpose of the Study:

  • To investigate the temporal and spatial expression of a novel C-type lectin, DDV10, during vaginal epithelial stratification and cornification.
  • To determine the relationship between DDV10 transcripts and estrogenic regulation in epithelial tissues.

Main Methods:

  • Analysis of DDV10 expression in ovariectomized mice treated with 17beta-estradiol (E2).
  • Examination of DDV10 expression in different regions of the mouse stomach.
  • Differential analysis of DDV10 and OCILrP1 mRNA expression in stratified and cornified epithelial tissues.

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  • Investigation of DDV10 expression in neonatally diethylstilbestrol (DES)-exposed mice.

    • Main Results:

    • DDV10 was expressed in the vagina following E2 treatment, but not in the uterus.
    • DDV10 expression was observed in the pars proventricularis of the mouse stomach.
    • Two transcripts, DDV10 (long form) and OCILrP1 (short form), were identified for the DDV10 gene.
    • Only DDV10 mRNA, not OCILrP1 mRNA, was detected in stratified and cornified epithelial tissues.
    • DDV10 mRNA expression in vaginal epithelium commenced 12-18 hours after E2 administration.
    • DDV10 mRNA was present in the vagina of neonatally DES-treated mice.

    Conclusions:

    • DDV10 is identified as the long form of C-type lectin domain family 2, member g (Clec2g-L).
    • DDV10/Clec2g-L expression is specifically associated with stratified and cornified epithelial tissues.
    • These findings suggest a significant role for DDV10/Clec2g-L in the processes of epithelial cell stratification and cornification during differentiation.