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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

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Related Experiment Video

Updated: Jul 22, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Cancer-related fatigue: A critical appraisal.

G Prue1, J Rankin, J Allen

  • 1Health and Rehabilitation Sciences Research Institute, University of Ulster, Room 14J17, Shore Road, Newtownabbey, Co. Antrim, Northern Ireland BT37 0QB, United Kingdom.

European Journal of Cancer (Oxford, England : 1990)
|February 8, 2006
PubMed
Summary

Cancer-related fatigue (CRF) is common during and after cancer treatment, but its prevalence and contributing factors remain unclear. Further research is needed to identify patterns and causes of CRF for better patient management.

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Related Experiment Videos

Last Updated: Jul 22, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Area of Science:

  • Oncology
  • Psychosocial Oncology
  • Cancer Survivorship

Background:

  • Cancer-related fatigue (CRF) is a prevalent and distressing symptom experienced by adult cancer patients.
  • Understanding the prevalence, patterns, and associated factors of CRF is crucial for effective management and improving quality of life.

Purpose of the Study:

  • To systematically review the existing literature on the prevalence and patterns of cancer-related fatigue (CRF).
  • To identify factors associated with the development and persistence of CRF in adult cancer patients.

Main Methods:

  • A systematic electronic database search was conducted using specified keywords.
  • Included studies focused on adult cancer patients and utilized multidimensional fatigue measures.
  • Methodological quality of the included studies was assessed using established standards.

Main Results:

  • CRF is present during and after anti-cancer therapy, with reported prevalence varying significantly across studies.
  • The specific variables linked to the development and persistence of CRF require further identification.
  • Inconsistencies were observed in the patterns of CRF and its associated factors, potentially due to measurement challenges.

Conclusions:

  • The prevalence of CRF is significant, but its patterns and associated factors are not well-defined.
  • Methodological limitations in current research, including subjective measurement and diverse outcome measures, hinder clear conclusions.
  • There is a need for more rigorous research that assesses CRF from therapy initiation and considers all relevant variables.