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Interleukin-1: a key inflammatory mediator in psoriasis?

John B Mee¹, Michael J Cork, Francesco S di Giovine

¹St John's Institute of Dermatology, King's College London, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK. john.mee@kcl.ac.uk

|February 8, 2006

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Interleukin-1 (IL-1) plays a key role in psoriasis inflammation. Increased IL-1beta in lesional skin suggests it

Area of Science:

Dermatology and immunology, focusing on inflammatory skin diseases.

Background:

The pro-inflammatory cytokine interleukin-1 (IL-1) is constitutively expressed by keratinocytes.
IL-1 is present in psoriatic lesional skin, suggesting a potential role in the disease.

Purpose of the Study:

To investigate the role of the IL-1 system in the inflammatory processes of psoriasis.
To compare gene expression profiles in psoriatic skin with IL-1 stimulated keratinocytes.

Main Methods:

Semi-quantitative RT-PCR and cRNA microarray analysis of lesional and non-lesional psoriatic skin biopsies.
Analysis of IL-1alpha, IL-1beta, IL-1 receptor transcripts, IL-1 receptor antagonist, and IL-8 expression.
Functional genomic comparison of transcriptome profiles.

Main Results:

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IL-1beta mRNA levels were markedly increased in lesional psoriatic skin.
IL-1-induced chemokine IL-8 expression was observed only in lesional epidermis.
Significant overlap was found between transcriptome profiles of psoriatic skin and IL-1 stimulated keratinocytes.

Conclusions:

IL-1 is likely a crucial mediator in the initiation and maintenance of psoriatic plaques.
The IL-1 system represents a potential therapeutic target for psoriasis treatment.