Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Within-host dynamics of antigenic variation.

Steven A Frank1, Alan G Barbour

  • 1Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697-2525, USA. safrank@uci.edu

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|February 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishment of a laboratory mouse model to study <i>Borrelia miyamotoi</i> infection and disease.

Frontiers in immunology·2026
Same author

<i>Xist</i> expression in male <i>Peromyscus leucopus</i> is associated with restricted chromatin repression and incomplete X-to-autosome dosage compensation.

bioRxiv : the preprint server for biology·2026
Same author

Generalization as the great leap in evolvability: insights from machine learning.

Evolution; international journal of organic evolution·2026
Same author

SARS-CoV-2 virus infection of <i>Peromyscus leucopus</i> demonstrates that infection tolerance is not limited to agents for which deermice are reservoirs.

bioRxiv : the preprint server for biology·2026
Same author

The Price Equation Reveals a Universal Force-Metric-Bias Law of Algorithmic Learning and Natural Selection.

Entropy (Basel, Switzerland)·2025
Same author

Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to a Toll-like receptor agonist.

Frontiers in immunology·2025

Parasites evade immune surveillance by switching surface antigens, creating diverse variants. Sequential outbreaks are dominated by specific types, a pattern potentially explained by favored gene expression pathways or immune selection biases.

Area of Science:

  • Parasitology
  • Immunology
  • Genetics

Background:

  • Parasites possess numerous surface antigens, expressing only one at a time.
  • Antigenic switching allows parasites to evade host immune responses.
  • Parasitemia occurs in outbreaks dominated by specific antigenic types.

Purpose of the Study:

  • To review prominent theories explaining sequential antigenic type dominance in parasitic infections.
  • To explore mechanisms creating favored connectivity pathways between antigenic variants.
  • To reanalyze data on variant transitions in Borrelia hermsii.

Main Methods:

  • Literature review of theories on parasitic antigenic variation.
  • Conceptual analysis of connectivity pathways in variant transition matrices.

Related Experiment Videos

  • Reanalysis of existing experimental data on Borrelia hermsii variant transitions.

    • Main Results:

    • Five prominent theories for sequential antigenic type dominance are reviewed.
    • Theories involving favored connectivity pathways are most promising.
    • Biased gene expression or immune selection may create these pathways.

    Conclusions:

    • Sequential dominance of antigenic types in parasitic infections is not fully explained.
    • Favored connectivity pathways, influenced by molecular or immune factors, offer a promising explanation.
    • Further research into these pathways is warranted.