Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

JAK/STAT signalling: STAT cannot play with Ken and Barbie.

James Castelli-Gair Hombría1, Sol Sotillos

  • 1Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/CSIC, Sevilla, Spain. jcashom@upo.es

Current Biology : CB
|February 8, 2006
PubMed
Summary

Cell-specific signaling pathways rely on KEN/BCL-6 repressors to select Signal Transducer and Activator of Transcription (STAT) targets. This ancestral mechanism is conserved across vertebrates and invertebrates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty.

Nature communications·2023
Same author

A conserved function of Human DLC3 and <i>Drosophila</i> Cv-c in testis development.

eLife·2022
Same author

Author Correction: Functional analysis of the Drosophila RhoGAP Cv-c protein and its equivalence to the human DLC3 and DLC1 proteins.

Scientific reports·2020
Same author

Evo-Devo: When Four Became Two Plus Two.

Current biology : CB·2020
Same author

Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia.

Nature communications·2018
Same author

Characterizing the embryonic development of B. hygida (Diptera: Sciaridae) following enzymatic treatment to permeabilize the serosal cuticle.

Mechanisms of development·2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Signaling

Background:

  • Signaling pathway activation leads to cell-specific transcriptional responses.
  • Signal Transducer and Activator of Transcription (STAT) proteins are key transcription factors involved in cellular signaling.
  • Understanding the regulation of STAT target selection is crucial for deciphering cell-specific gene expression.

Purpose of the Study:

  • To investigate the role of sequence-specific transcriptional repressors in STAT target selection.
  • To determine if this mechanism is conserved across different species.

Main Methods:

  • Analysis of transcriptional responses to signaling pathway activation.
  • Identification of sequence-specific transcriptional repressors involved in STAT binding.

Related Experiment Videos

  • Comparative analysis across vertebrates and invertebrates.

    • Main Results:

    • The KEN/BCL-6 family of sequence-specific transcriptional repressors significantly influences STAT target selection.
    • This regulatory mechanism was observed in both vertebrate and invertebrate species.
    • Evidence suggests a shared ancestral mechanism for STAT target selection.

    Conclusions:

    • The KEN/BCL-6 family plays a critical role in mediating cell-specific transcriptional responses by regulating STAT targets.
    • The findings indicate that STAT proteins likely utilize an evolutionarily conserved mechanism for target gene regulation.