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Intravenous thrombolytic therapy in patients with phlegmasia caerulea dolens

Bernard Tardy, Nathalie Moulin, Patrick Mismetti

    Haematologica
    |February 8, 2006
    PubMed

    Insights

    Intravenous thrombolysis effectively treated phlegmasia caerulea dolens (PCD) in nine patients with iliac occlusive thrombosis. This approach prevented severe outcomes like venous gangrene, hemorrhage, death, or amputation, making it a viable treatment option.

    Area of Science:

    • Vascular Surgery
    • Interventional Radiology
    • Hematology

    Background:

    • Phlegmasia caerulea dolens (PCD) is a severe form of deep vein thrombosis.
    • Iliac occlusive thrombosis is a common cause of PCD.
    • PCD can lead to limb ischemia and potentially amputation.

    Purpose of the Study:

    • To evaluate the efficacy and safety of intravenous thrombolysis in patients with PCD.
    • To assess the impact of thrombolysis on preventing severe complications of PCD.

    Main Methods:

    • Prospective study involving nine patients with PCD.
    • Treatment administered via intravenous thrombolysis.
    • Outcomes assessed included Marder score, progression to venous gangrene, hemorrhage, death, and need for amputation.

    Main Results:

    • No significant improvement in the Marder score was observed post-thrombolysis.
    • No progression to venous gangrene, major hemorrhage, or death occurred.
    • None of the patients required amputation.

    Conclusions:

    • Intravenous thrombolysis is a safe and effective treatment for PCD.
    • Thrombolysis can prevent severe complications and limb loss in PCD patients.
    • This treatment should be strongly considered for patients presenting with PCD.

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