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Updated: Aug 11, 2026

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
Harnessing the immune system against human glioma
Kavita M Dhodapkar1, Devi Banerjee, Ralph M Steinman
1The Rockefeller University, Laboratory of Cellular Physiology & Immunology, 1230 York Ave., New York, NY 10021, USA. dhodapk@mail.rockefeller.edu
Abstract:
Our studies are directed toward immune resistance to glial tumors, particularly in children. Initial experiments indicate that it is possible to boost both innate natural killer T lymphocytes and adaptive CD4+ and CD8+ T cells by targeting the appropriate antigens to dendritic cells. Our hypothesis is that optimal vaccination approaches against cancer will need to recruit both innate and adaptive defense mechanisms.

