Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Application of sequence-based methods in human microbial ecology.

Li Weng1, Edward M Rubin, James Bristow

  • 1Joint Genome Institute, Walnut Creek, California 94598, USA.

Genome Research
|February 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026.

Intensive care medicine·2026
Same author

Performance of sequential organ failure assessment 1 versus 2 for sepsis identification in patients with suspected infection: a multicenter retrospective cohort study.

Critical care (London, England)·2026
Same author

CAR-NK cell therapy for hematologic malignancies: advances, challenges and optimization strategies.

Molecular cancer·2026
Same author

Correlation analysis of coagulation factor level and chronic low-grade inflammation in patients with type 2 diabetes mellitus complicated with ischemic stroke.

Open medicine (Warsaw, Poland)·2026
Same author

Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.

Critical care medicine·2026
Same author

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.

Critical care medicine·2026
Same journal

Complete sequencing of medaka genomes reveals the architecture of centromeric satellites, giant mobile elements, and sex chromosomes.

Genome research·2026
Same journal

Convergence and conflict among telomere specialized transposons across 60 million years of Drosophilid evolution.

Genome research·2026
Same journal

A unified analysis of cell type- and trajectory-associated pathways in single-cell data using Phoenix.

Genome research·2026
Same journal

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin.

Genome research·2026
Same journal

Telomere-driven replicative crisis is driven by large-scale changes in genomic architecture.

Genome research·2026
Same journal

Spatially informed reference-free cell-type deconvolution for spatial transcriptomics with SpatialCD.

Genome research·2026
See all related articles

Sequence-based methods are revolutionizing microbial analysis, enabling the exploration of microbial diversity and function. These techniques are increasingly applied to human health, aiding in pathogen identification and understanding human-microbe interactions.

Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • Ecologists have long acknowledged the complexity of microbial diversity.
  • Culture-independent, high-throughput DNA sequencing methods have greatly advanced environmental microbial studies.
  • Application of these advanced techniques to human health and disease has been limited until recently.

Purpose of the Study:

  • To review available sequence-based methods for microbial analysis.
  • To discuss the application of these methods to human health and disease.
  • To highlight the potential for identifying novel pathogens, improving diagnostics, and understanding human-microbial relationships.

Main Methods:

  • Review of current sequence-based microbial analysis techniques.
  • Discussion of DNA-based methods for cataloging microbial diversity and function.

Related Experiment Videos

  • Exploration of applications in human health and disease contexts.

    • Main Results:

    • Sequence-based methods offer detailed insights into microbial diversity and function.
    • These techniques are beginning to be applied to human-associated microbial communities.
    • Potential exists for identifying novel pathogens and improving infectious disease diagnostics.

    Conclusions:

    • Sequence-based methods represent a powerful tool for studying microbial communities.
    • Their application to human health, termed the "second Human Genome Project," holds significant promise.
    • Further research can advance our understanding of human-microbial interactions and disease pathogenesis.