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Related Experiment Videos

Urticaria and hepatitis.

Bernard Cribier1

  • 1Clinique Dermatologique, University Hospital, Strasbourg, France. bernard.cribier@chru-strasbourg.fr

Clinical Reviews in Allergy & Immunology
|February 8, 2006
PubMed
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Acute urticaria can signal viral hepatitis infections like A, B, and C. However, scientific evidence does not link hepatitis B or C virus infections to chronic urticaria.

Area of Science:

  • Hepatology
  • Dermatology
  • Immunology

Background:

  • Acute urticaria is a recognized prodromic symptom in viral hepatitis A and B, and less commonly in hepatitis C.
  • Urticaria in viral hepatitis is associated with immune-complex deposition and may present as part of Caroli's triad (urticaria, arthritis, headache).
  • The presentation of acute urticaria is nonspecific, often mimicking cutaneous symptoms from other viral infections.

Purpose of the Study:

  • To review the association between viral hepatitis infections and urticaria, differentiating between acute and chronic forms.
  • To evaluate the evidence linking hepatitis B and C virus infections to chronic urticaria.
  • To assess the clinical utility of routine hepatitis virus screening in patients with chronic urticaria.

Main Methods:

Related Experiment Videos

  • Literature review and synthesis of existing studies on viral hepatitis and urticaria.
  • Analysis of case reports and clinical series concerning hepatitis C and chronic urticaria.
  • Evaluation of controlled studies investigating the hepatitis C-chronic urticaria relationship.

    • Main Results:

    • Acute urticaria is a potential early indicator of hepatitis A, B, and C.
    • No convincing evidence supports a causal link between hepatitis B or C virus infection and chronic urticaria.
    • Hepatitis B or C can be associated with urticarial vasculitis, distinct from true urticaria.

    Conclusions:

    • While acute urticaria may be a prodromal symptom of viral hepatitis, chronic urticaria is not convincingly linked to hepatitis B or C.
    • Routine hepatitis virus testing in chronic urticaria patients is likely not cost-effective.
    • Urticarial vasculitis in hepatitis B or C is more likely a manifestation of vasculitis than urticaria.