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Chronic urticaria and thyroid auto-immunity.

Marie-Sylvie Doutre1

  • 1Department of Dermatology, Université Victor-Segalen, Hôpital Haut-Lévêque, Pessac, France. marie-sylvie.doutre@chu-bordeaux.fr

Clinical Reviews in Allergy & Immunology
|February 8, 2006
PubMed
Summary

Thyroid auto-immunity is linked to chronic urticaria (CU), with antithyroid antibodies (ATAs) found in 12-29% of patients. These antibodies likely represent parallel autoimmune events rather than a direct cause of CU.

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Area of Science:

  • Immunology
  • Endocrinology
  • Dermatology

Background:

  • The link between thyroid autoimmunity and chronic urticaria (CU) is well-established.
  • Prevalence of antithyroid antibodies (ATAs) in CU patients ranges from 12% to 29%.
  • The direct causative role of ATAs in CU remains debated.

Purpose of the Study:

  • To explore the relationship between thyroid autoimmunity and chronic urticaria.
  • To investigate the potential role of antithyroid antibodies in CU pathogenesis.
  • To assess the implications of associated autoimmune phenomena.

Main Methods:

  • Review of existing literature on thyroid autoimmunity and chronic urticaria.
  • Analysis of prevalence data for antithyroid antibodies (ATAs).
  • Examination of associations with anti-immunoglobulin E receptor antibodies.

Main Results:

  • Antithyroid antibodies (ATAs) are frequently observed in patients with chronic urticaria (CU).
  • Evidence suggests ATAs are not a direct cause of CU but may indicate parallel autoimmune processes.
  • Association with anti-immunoglobulin E receptor antibodies noted in some cases.

Conclusions:

  • Thyroid autoimmunity and chronic urticaria (CU) share an association, often involving antithyroid antibodies (ATAs).
  • ATAs in CU patients likely signify concurrent autoimmune conditions rather than direct causation.
  • Further controlled trials are needed to evaluate hormonal treatments for CU symptoms.

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