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Preparation and evaluation of solid dispersion of meloxicam with skimmed milk

Sengodan Gurusamy Vijaya Kumar1, Dina Nath Mishra

  • 1Department of Pharmaceutical Sciences, Guru Jambheshwar University, Haryana, India. sgvijay@yahoo.com

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|February 8, 2006
PubMed

Insights

This study enhanced the solubility and dissolution of meloxicam (MLX), a non-steroidal anti-inflammatory drug, using solid dispersions with skimmed milk. This formulation shows potential for treating gastric disturbances.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Meloxicam (MLX) is a water-insoluble non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor.
  • Poor aqueous solubility limits the therapeutic efficacy and formulation options for MLX.

Purpose of the Study:

  • To enhance the aqueous solubility and dissolution rate of meloxicam.
  • To investigate the potential of solid dispersions with skimmed milk for improving MLX properties.

Main Methods:

  • Preparation of physical mixtures and solid dispersions of MLX with skimmed milk.
  • Utilized rotary vacuum evaporation technique for solid dispersion preparation.
  • Characterization using Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM).

Main Results:

  • Solid dispersions significantly increased MLX aqueous solubility (approximately threefold) compared to the pure drug.
  • Dissolution rate was notably improved for solid dispersions versus physical mixtures and pure MLX.
  • Analytical techniques confirmed the formation of meloxicam-skimmed milk solid dispersions.

Conclusions:

  • Solid dispersion with skimmed milk effectively enhances meloxicam solubility and dissolution.
  • The presence of amino acids and surfactants in skimmed milk contributes to solubility enhancement.
  • This approach offers a promising strategy for formulating water-insoluble drugs like MLX for potential gastrointestinal applications.

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