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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic esophagitis: treatment in 2005
1University of Pennsylvania School of Medicine, Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. liacouras@email.chop.edu
Current Opinion in Gastroenterology
|February 8, 2006
Summary
Eosinophilic esophagitis (EoE) is a rising allergic condition diagnosed via esophageal biopsy. Treatment involves dietary antigen elimination and medical therapies.
Area of Science:
- Gastroenterology
- Allergology
- Pediatrics
Background:
- Eosinophilic esophagitis (EoE) is an esophageal inflammation often misdiagnosed as gastroesophageal reflux.
- Recent literature shows a significant increase in EoE research, highlighting its rising incidence.
Purpose of the Study:
- To review recent literature on eosinophilic esophagitis pathophysiology and treatment.
- To inform physicians about EoE's clinical presentation and management.
Main Methods:
- Literature review focusing on the past year's publications.
- Analysis of diagnostic criteria including endoscopy with biopsy.
- Evaluation of treatment strategies.
Main Results:
- EoE etiology in children is linked to allergic responses to food antigens.
- Diagnosis requires esophageal biopsy showing >20 eosinophils/HPF, normal stomach/duodenum biopsies, and symptom resolution with diet changes.
- Commonly implicated foods include milk, eggs, nuts, wheat, soy, and others.
Conclusions:
- This review synthesizes current knowledge on EoE pathophysiology and treatment.
- Highlights the importance of understanding EoE for effective patient management.
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