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Sinonasal undifferentiated carcinoma.

William M Mendenhall1, Charles M Mendenhall, Charles E Riggs

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610-0385, USA. mendewil@shands.ufl.edu

American Journal of Clinical Oncology
|February 8, 2006
PubMed
Summary

Optimal treatment for sinonasal undifferentiated carcinoma involves craniofacial resection with adjuvant radiotherapy (RT) and chemotherapy. Despite this, relapse risks remain high, with modest cure rates for this rare cancer.

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Area of Science:

  • Head and Neck Oncology
  • Skull Base Surgery
  • Radiation Oncology

Background:

  • Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive malignancy.
  • Patients often present with locally advanced disease and regional lymph node involvement.

Purpose of the Study:

  • To review the treatment strategies and patient outcomes for sinonasal undifferentiated carcinoma.
  • To identify optimal therapeutic approaches for SNUC.

Main Methods:

  • Literature review of relevant studies on SNUC treatment.
  • Analysis of treatment combinations including surgery, radiotherapy (RT), and chemotherapy.

Main Results:

  • High rates of local-regional recurrence (20-30%+) and distant dissemination (25-30%) are observed.

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  • Cure rates for SNUC range from 20% to 50%, with better outcomes in patients receiving craniofacial resection plus RT/chemotherapy.
  • Incompletely resectable tumors may benefit from definitive RT and adjuvant chemotherapy.

    • Conclusions:

    • Craniofacial resection combined with adjuvant RT (with or without chemotherapy) is the preferred treatment for SNUC.
    • The risk of relapse is significant, and the overall probability of cure remains modest.
    • Definitive chemoradiation offers a potential cure for patients with unresectable SNUC.