Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Adrenergic Receptors (Adrenoceptors): Classification

Adrenergic Receptors (Adrenoceptors): Classification

Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors, which are found on postsynaptic...

Adrenergic Receptors: β Subtype

Adrenergic Receptors: β Subtype

β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which indirectly block calcium...

Heart Failure Drugs: β-Blockers

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PM<sub>2.5</sub> elemental composition in indoor residential environments and co-exposure effects on respiratory health in an industrial area.

Environmental research·2022

Same author

Assessment of the link between atmospheric dispersion and chemical composition of PM<sub>10</sub> at 2-h time resolution.

Chemosphere·2022

Same author

A combined chemical/size fractionation approach to study winter/summer variations, ageing and source strength of atmospheric particles.

Environmental pollution (Barking, Essex : 1987)·2019

Same author

Biomass burning contribution to PM<sub>10</sub> concentration in Rome (Italy): Seasonal, daily and two-hourly variations.

Chemosphere·2019

Same author

Correlation of preoperative findings in computed axial tomography with the presence of difficult airway in patients undergoing head and neck otorhinolaryngological surgery.

Revista espanola de anestesiologia y reanimacion·2018

Same author

Chemical characterization of indoor and outdoor fine particulate matter in an occupied apartment in Rome, Italy.

Indoor air·2015

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

Isolation, Culture, and Functional Characterization of Adult Mouse Cardiomyoctyes

Isolation, Culture, and Functional Characterization of Adult Mouse Cardiomyoctyes

Published on: September 25, 2013

Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.

C Perrino¹, G Esposito, H A Rockman

¹Department of Medicine, Cell Biology and Molecular Genetics, Duke University Medical Center, Durham, NC, USA.

Panminerva Medica

|February 8, 2006

Summary

This summary is machine-generated.

This review examines the controversial role of beta-adrenergic receptor (betaAR) signaling in heart failure. It explores how betaAR dysfunction impacts failing heart cells and discusses strategies to normalize signaling for improved contractility.

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Related Experiment Videos

Last Updated: Jul 9, 2026

Isolation, Culture, and Functional Characterization of Adult Mouse Cardiomyoctyes

Isolation, Culture, and Functional Characterization of Adult Mouse Cardiomyoctyes

Published on: September 25, 2013

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Area of Science:

Cardiology
Molecular Biology
Pharmacology

Background:

Heart failure is linked to elevated catecholamines and altered beta-adrenergic receptor (betaAR) systems.
The precise impact of reduced betaAR signaling on failing cardiomyocytes remains debated.

Purpose of the Study:

To review studies on the role of betaAR dysfunction in heart failure progression.
To explore novel strategies for normalizing betaAR signaling to enhance cardiomyocyte function.

Main Methods:

Literature review of studies investigating beta-adrenergic receptor signaling in heart failure.
Analysis of research on cardiomyocyte contractility and betaAR modulation.

Main Results:

Beta-adrenergic receptor system is extensively abnormal in heart failure.
The effect of dampening betaAR signals in failing cardiomyocytes is controversial.

Conclusions:

Understanding betaAR dysfunction is crucial for heart failure progression.
Normalizing betaAR signaling presents a potential therapeutic strategy for heart failure.