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Hydrophilic absorbable copolyester exhibiting zero-order drug release
Sasa Andjelić1, Jenny Yuan, Dennis D Jamiolkowski
1Procedural Implants R&D, Ethicon, a Johnson & Johnson Company, Route 22 West, Somerville, New Jersey 08876-0151, USA. sandjeli@ethus.jnj.com
Pharmaceutical Research
|February 8, 2006
Summary
This study introduces a new absorbable hydrophilic copolyester for medical devices. The material demonstrates controlled drug release with minimal burst effect and unique water diffusion properties, suggesting broad medical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- A novel amorphous 40/60 poly(ethylene diglycolate-co-glycolide) hydrophilic copolyester was developed.
- This material exhibits desirable physical properties for in-vivo medical applications, including transparency, elasticity, and durability.
Purpose of the Study:
- To investigate the in-vitro drug release characteristics of the novel copolyester.
- To evaluate the material's potential for controlled drug delivery applications.
Main Methods:
- High Performance Liquid Chromatography (HPLC) was used to determine drug release profiles.
- Dielectric relaxation spectroscopy and infrared spectroscopy analyzed polymer chain interactions with water and buffer solutions at 37°C.
- In-vitro hydrolysis studies were conducted to assess material degradation.
Main Results:
- The copolyester film demonstrated nearly constant in-vitro release of both hydrophilic and hydrophobic drugs, with minimal to no burst effect.
- Hydrolysis studies showed an extended induction period (up to 6 days) before relatively rapid degradation.
- Spectroscopic data indicated a lack of structural association between water molecules and polymer chains during the initial hydrolysis phase.
Conclusions:
- The unique water diffusion dynamics within the polymer matrix are crucial for achieving controlled drug release.
- The observed molecular interactions and properties of this synthetic absorbable material hold significant potential for advanced medical applications.
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