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Pulsed arterial spin labeling parameter optimization for an elderly population.

Alison M Campbell1, Christian Beaulieu

  • 1Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada T6G 2V2.

Journal of Magnetic Resonance Imaging : JMRI
|February 8, 2006
PubMed
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Optimizing pulsed arterial spin labeling (PASL) for the elderly requires longer inversion times (TI(2)) to account for age-related brain perfusion changes and minimize intravascular signal.

Area of Science:

  • Neuroimaging
  • Medical Physics
  • Gerontology

Background:

  • Cerebral blood flow (CBF) and perfusion dynamics can change with age.
  • Pulsed arterial spin labeling (PASL) is a non-invasive MRI technique to measure CBF.
  • Optimizing PASL parameters is crucial for accurate assessment in diverse age groups.

Purpose of the Study:

  • To determine optimal PASL parameters for elderly individuals.
  • To investigate age-related differences in brain perfusion using PASL.
  • To minimize intravascular signal artifacts in PASL for older adults.

Main Methods:

  • Utilized Q2TIPS (QUIPSS II with thin-slice TI, periodic saturation) PASL at 1.5T.
  • Scanned healthy young and elderly subjects with varying inversion times (TI(2)).

Related Experiment Videos

  • Calculated perfusion-weighted signal difference (DeltaM), transit time (deltat), and CBF in gray matter.

    • Main Results:

    • Elderly subjects showed lower perfusion-weighted signal difference compared to young subjects.
    • Peak signal difference occurred at longer inversion times in the elderly (1500 msec) versus young (1300 msec).
    • A longer TI(2) of 1800 msec was needed to minimize intravascular signal in the elderly.

    Conclusions:

    • A longer inversion time (TI(2)) is advantageous for PASL in the elderly.
    • This optimization ensures minimal intravascular signal and adequate tissue signal for accurate cerebral perfusion assessment.
    • Findings aid in refining PASL protocols for geriatric neuroimaging studies.