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Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice
Published on: September 19, 2019
[Clinical study on bacterial translocation in severe multiple trauma patients]
Zhi Qiao1, Zhan-liang Li, Ji-ye Li
1First Affiliated Hospital of General Hospital of PLA, Beijing 100037, China. drqiaozhi@yahoo.com.cn
Summary
Bacterial translocation, indicated by microbial DNA in blood, occurs early after severe trauma. Polymerase chain reaction (PCR) detection of bacterial DNA can predict sepsis and infection in trauma patients.
Area of Science:
- Critical Care Medicine
- Microbiology
- Molecular Diagnostics
Context:
- Severe multiple trauma patients are at high risk for infectious complications.
- Early detection of bacterial translocation is crucial for timely intervention.
Purpose:
- To investigate bacterial translocation in severe multiple trauma patients.
- To assess the utility of polymerase chain reaction (PCR) for detecting microbial DNA in blood.
- To correlate bacterial translocation with sepsis and infectious complications.
Summary:
- Microbial DNA was detected in 62.5% of severe trauma patients within 2 hours post-trauma using PCR.
- PCR positivity strongly correlated with sepsis (100%) and infectious complications (70%).
- Blood cultures had lower sensitivity (18.75%) compared to PCR.
Impact:
- Early bacterial translocation, primarily E. coli, is identified as a significant event post-trauma.
- PCR detection of microbial DNA serves as a valuable tool for predicting sepsis and infection.
- Findings suggest PCR can guide early therapeutic strategies in trauma care.
