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The effect of polycarbophil gel (Replens) on bacterial vaginosis: a pilot study
Justine P Wu1, Stephen L Fielding, Kevin Fiscella
1University of Rochester, Highland Hospital, Department of Family Medicine Research Programs, 1381 South Avenue, Rochester, NY 14620, USA. drwuju1@yahoo.com
Objective:
To determine if use of intravaginal polycarbophil gel (Replens) for 1 month will: (1) lower vaginal pH; (2) improve signs of bacterial vaginosis (BV).
Study Design:
Seventeen women with BV self-administered polycarbophil gel every third day for 4 weeks in an open-label, prospective pilot study. Primary outcome measures included vaginal pH, presence of amines and Nugent scores.
Results:
At week 4, there was improvement in Nugent scores, vaginal odor and clue cell count (p<0.05). Eleven women converted from amine positive to negative (73+/-20%). There was no significant change in vaginal pH.
Conclusions:
Polycarbophil gel is associated with improved signs of BV, although not vaginal pH.
