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Updated: Aug 11, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Antibacterial activity of (-)-deoxypseudophrynaminol versus its racemate and derivatives
Andrew V Dix1, Carly M Meseck, Adam J Lowe
1Department of Chemistry, Henson School of Science and Technology, Salisbury University, Salisbury, MD 21801, USA.
Abstract:
(-)-Deoxypseudophrynaminol 1 possesses 43-fold greater antibacterial potency than the racemate toward Staphylococcus aureus, indicating that the (-)-enantiomer is the biologically active isomer in this assay. Comparison of the percent growth inhibition by derivatives of 1 indicates that prenylation of N8 and replacement of N1-methyl by methyl carbamate are detrimental to antibacterial potency. (-)-1 is a promising lead structure for the development of the novel hexahydropyrrolo[2,3-b]indole class of antibacterial agents.
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