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New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA
Jun-ya Ueda1, Lisa Imamura, Yasuhiro Tezuka
1Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Abstract:
Agarwood, one of the valuable non-timber products in tropical forest, is a fragrant wood, whose ethereal fragrance has been prized in Asia for incense in ceremony, as well as sedatives in traditional medicine. We separated the 70% EtOH extract of Vietnamese agarwood, which showed significant induction effect on brain-derived neurotrophic factor (BDNF) mRNA expression in rat cultured neuronal cells, to isolate a new compound and a 2-(2-phenylethyl)chromone derivative. The new compound was determined to be a spirovetivane-type sesquiterpene, (4R,5R,7R)-1(10)-spirovetiven-11-ol-2-one, by spectroscopic data and showed induction effect of BDNF mRNA.
