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Published on: November 7, 2018
Adefovir dipivoxil-associated thrombocytopenia in a patient with chronic hepatitis B
G Stornaiuolo1, A Amato, G B Gaeta
1Unit of Viral Hepatitis, Department of Infectious Diseases, Second University of Naples, Via Cotugno 1, 80135 Naples, Italy.
Abstract:
A 56-year-old male patient received adefovir dipivoxil (10 mg/day) for chronic hepatitis B resistant to lamivudine. On the fifth week of treatment, the platelet count dropped to 26 x 10(3) mm(-3); anti-platelet antibodies were detectable in serum. The drug was discontinued and the platelet count improved spontaneously. A re-challenge with adefovir caused a new episode of thrombocytopenia, again after a five-week treatment period. To date, thrombocytopenia has not been described after adefovir therapy for chronic hepatitis B and seems to be a rare event.
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