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Bortezomib-induced Sweet's syndrome.

N Van Regenmortel1, K Van de Voorde, H De Raeve

  • 1Division of Haematology, Antwerp University Hospital.

Haematologica
|February 9, 2006
PubMed
Summary

Drug-induced Sweet's syndrome is a rare skin condition. This report details two cases linked to bortezomib, a proteasome inhibitor, fulfilling diagnostic criteria and excluding other conditions.

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Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Sweet's syndrome is an uncommon acute febrile neutrophilic dermatosis.
  • Drug-induced Sweet's syndrome is a rare variant, often associated with medications.
  • Proteasome inhibitors are used in cancer therapy and can have various side effects.

Observation:

  • Two cases of Sweet's syndrome were observed in patients receiving bortezomib.
  • The patients met the diagnostic criteria for drug-induced Sweet's syndrome.
  • Vasculitis and neutrophilic eccrine hidradenitis were ruled out in both cases.

Findings:

  • Bortezomib, a proteasome inhibitor, was identified as the causative agent.
  • The clinical presentation and diagnostic criteria confirmed drug-induced Sweet's syndrome.

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  • Exclusion of vasculitis and neutrophilic eccrine hidradenitis supports the diagnosis.

    • Implications:

    • This highlights a rare but significant adverse drug reaction to bortezomib.
    • Awareness of this association is crucial for early diagnosis and management.
    • Further research may be needed to understand the mechanism of bortezomib-induced Sweet's syndrome.