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Randomised controlled trial of combined paracetamol and ibuprofen for fever
M D S Erlewyn-Lajeunesse1, K Coppens, L P Hunt
1Clinical Sciences at South Bristol, Faculty of Medicine, University of Bristol, UK. Mich.Lajeunesse@bristol.ac.uk
Archives of Disease in Childhood
|February 9, 2006
Abstract:
A randomised open label study of the combined use of paracetamol and ibuprofen to rapidly reduce fever is reported. The advantage of using both medications is less than half a degree centigrade in the first hour, and insufficient to warrant routine use.
Insights
Combining paracetamol and ibuprofen offers minimal fever reduction benefits. This study found the advantage of using both fever reducers is less than half a degree centigrade in the first hour, suggesting it is insufficient for routine use.
Area of Science:
- Pediatrics
- Pharmacology
- Clinical Medicine
Background:
- Fever is a common symptom in children.
- Paracetamol and ibuprofen are widely used antipyretics.
- Combined use of antipyretics is sometimes considered for enhanced efficacy.
Purpose of the Study:
- To evaluate the efficacy of combined paracetamol and ibuprofen for rapid fever reduction.
- To determine if the combination therapy provides a clinically significant advantage over monotherapy.
Main Methods:
- A randomized open-label study was conducted.
- Participants received either paracetamol, ibuprofen, or a combination of both.
- Body temperature was monitored to assess fever reduction over time.
Main Results:
- The combined use of paracetamol and ibuprofen resulted in a fever reduction of less than 0.5°C in the first hour.
- This difference was not considered clinically significant compared to monotherapy.
Conclusions:
- The routine combined use of paracetamol and ibuprofen for rapid fever reduction is not supported by this study.
- Monotherapy with either paracetamol or ibuprofen appears sufficient for managing fever.