Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Less death in the dying.

K Polyak1, T T Wu, S R Hamilton

  • 1The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 424. N. Bond St. Baltimore, Maryland 21231, USA.

Cell Death and Differentiation
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analytical validation of HER2DX genomic test for early-stage HER2-positive breast cancer.

ESMO open·2024
Same author

Erratum to "Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation" [Diagn. Interv. Imaging. 101 (2020) 35-44].

Diagnostic and interventional imaging·2020
Same author

Differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma with CT radiomics features.

Diagnostic and interventional imaging·2020
Same author

Deep lessons learned: Radiology, oncology, pathology, and computer science experts unite around artificial intelligence to strive for earlier pancreatic cancer diagnosis.

Diagnostic and interventional imaging·2019
Same author

Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation.

Diagnostic and interventional imaging·2019
Same author

Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same journal

Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis.

Cell death and differentiation·2026
Same journal

Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.

Cell death and differentiation·2026
Same journal

Ssu72 phosphatase orchestrates obesogenic adipogenesis and metabolic homeostasis during nutrient excess.

Cell death and differentiation·2026
Same journal

SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice.

Cell death and differentiation·2026
Same journal

LFPM inhibition of RING1-mediated p53<sup>R175H</sup> degradation drives oncogenesis in p53<sup>R175H</sup>-mutant cancers.

Cell death and differentiation·2026
Same journal

Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer.

Cell death and differentiation·2026
See all related articles

Aging impairs immune function, partly due to reduced apoptosis. This study found age-dependent decreases in radiation-induced apoptosis in mouse splenic lymphocytes, suggesting a mechanism for immune decline with advanced age.

Area of Science:

  • Immunology
  • Gerontology
  • Cell Biology

Background:

  • Age-associated diseases are leading causes of death.
  • Cancer risk and immune system decline increase with age.
  • Apoptosis is crucial for cancer prevention and immune function.

Purpose of the Study:

  • To investigate the relationship between aging and apoptosis following gamma irradiation.
  • To determine if apoptosis changes with age in different cell types.

Main Methods:

  • Mice of various ages were exposed to gamma irradiation.
  • Apoptosis levels were measured in splenic lymphocytes and colorectal epithelial cells.

Main Results:

  • A significant age-dependent decrease in radiation-induced apoptosis was observed in splenic lymphocytes.

Related Experiment Videos

  • Apoptosis in colorectal epithelial cells did not show a similar age-dependent decrease.

    • Conclusions:

    • The decline in splenic lymphocyte apoptosis with age may contribute to age-related immune dysfunction.
    • These findings offer insights into the mechanisms underlying immune system deterioration in aging individuals.