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Updated: Aug 11, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
New aldose reductase inhibitors N99-596 A and B from Streptomyces
Yuesheng Dong1, Junshan Yang, Xiao Ren
1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People's Republic of China. jsyang2005@yahoo.cn
Abstract:
The actinomycete Streptomyces diannanensis, isolated from a soil sample collected in Yunnan province, China, was found to produce two novel isoflavone rhamnopyranosides, namely, 7,4'-dihydroxyisoflavone 3'-O-alpha-L-rhamnopyranoside (1) and 5,7,4'-trihydroxyisoflavone 3'-O-alpha-L-rhamnopyranoside (2). The structures of 1 and 2 were elucidated on the basis of extensive 1D and 2D NMR and MS spectral analyses. Compounds 1 and 2 exhibited in vitro activities against aldose reductase with an IC50 of 170 and 165 microM, respectively.
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