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Updated: Aug 11, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
Published on: December 14, 2011
Gender differences in amino acid use during endurance exercise
1Exercise Science Program, University of Rhode Island, Kingston, RI, USA. LLA4983U@postoffice.uri.edu
Abstract:
There are gender differences in the substrate used to fuel prolonged physical activity. Males rely on carbohydrate and amino acids (97%), while females use predominantly fat (62%) to fuel endurance exercise. This review looks at the mechanisms that regulate these gender differences, with a focus on amino acid metabolism. Gender-selective nutritional recommendations are indicated for physically active individuals and some cardiac patients who engage in intense aerobic activity.
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